Indian Drugs Database:
Drugs and Medications
Patients all over the world should be informed about the existence of Drug Information Database as they all at least once in their life face the necessity of taking some unknown medications. It is evident people mustn’t blindly use medications without learning some main information about the chosen medicine, otherwise they may bring much harm to their own health.
Drug Information Database was created to simplify our search and to satisfy our inquiries. This database contains product specific information on medications approved for use in your country. It is worth mentioning that Drug Information Database is managed by government regulatory body concerning health and includes human pharmaceutical and biological drugs, veterinary drugs and disinfectant products; it contains approximately 15,000 products which companies have notified department of health as being marketed.
As a rule information available in the Drug Information Database consists of the following main parameters: brand name; description field; drug identification number (DIN); company; drug statuses; status date; class; active ingredient(s); strength; route(s) of administration; pharmaceutical form(s); product monograph (PM); schedule; therapeutic classification (AHFS and ATC); active ingredient group (AIG) number; veterinary species.
Patients should note that Drug Information Database is necessary for driving and supporting a person in the huge medical sphere by providing such drug databases within information systems. Usually the authors of these databases create a profitable partnership with the system developer customers to integrate the drug databases to improve user workflow, enhance clinical decision making at the point-of-need, and give a helping hand to reduce the incidence of medication errors and adverse drug events.
In general, Drug Information Database provides a client with the main facts and general knowledge about the chosen medications; it explains why they are used and some, but not all, of the possible side effects.
However, a person is to keep in mind that this guide should not be used as a substitute for a detailed discussion with your physician and pharmacist about drugs you are being given. If you experience any side effect after taking the drug, even if they are not noted below, consult your doctor immediately.
  • Database Of Indian Drugs & Medications
Medicines Database: Indian Drugs Database

Atorvastatin (Lipitor, Pfizer), is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms.

Triptorelin, a decapeptide, is a gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals).

Pralidoxime belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. It is used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents), in conjunction with atropine and diazepam. Pralidoxime is most commonly in the form of Pralidoxime Chloride, also known as 2-PAM Cl (or just 2-PAM by the military). As the iodide salt (methiodide), it is also called pyridine aldoximine methiodide or pyridine aldoxime methiodide (PAM).

Chlordiazepoxide and amitriptyline hydrochloride tablets combine for oral administration, chlordiazepoxide, an agent for the relief of anxiety and tension, and amitriptyline, an antidepressant. Each film coated tablet for oral administration contains 5 mg chlordiazepoxide and 12.5 mg amitriptyline (as the hydrochloride salt) or 10 mg chlordiazepoxide and 25 mg amitriptyline as the hydrochloride salt).

Information Not Available

Mupirocin (Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens NCIMB 10586, developed by Beecham.

Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. It is used topically and is effective against Gram-positive bacteria, including MRSA. Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. Also present in mupirocin are pseudomonic acid B with an additional hydroxyl group at C8, pseudomonic acid C with a double bond between C10 and C11, instead of the epoxide of PA-A, and pseudomonic acid D with a double bond at C4` and C5` in the 9-hydroxy-nonanoic acid portion of mupirocin.

Atenolol is a selective ?1 receptor antagonist, a drug belonging to the group of ?-blockers, a class of drugs used primarily in Cardiovascular diseases. Introduced in 1976, atenolol was developed as a replacement for propranolol in the treatment of hypertension. The chemical works by slowing down the heart and reducing its workload. Unlike propranolol, atenolol does not pass through the blood-brain barrier thus avoiding various CNS side effects.

Whilst atenolol, the most widely used ?-blocker in the United Kingdom, was once first-line treatment for hypertension, the role for ?-blockers in hypertension was downgraded in June 2006 in the United Kingdom to fourth-line as they perform less well than other drugs, particularly in the elderly, and there is increasing evidence that the most frequently used ?-blockers at usual doses carry an unacceptable risk of provoking type 2 diabetes.

Amphotericin B is a polyene antifungal drug, often used intravenously for systemic fungal infections.

Mexiletine belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart - or seriously irregular heartbeats. It slows nerve impulses in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.

Class IB antiarrhythmics decrease action potential duration by shortening the repolarization phase. This is achieved by blocking sodium channels.

Mexiletine may also be of use in patients experiencing refractory pain. (Sweetman, 2002) and is also effective for treating muscle stiffness resulting from myotonia congenita (Thomsen disease) or myotonic dystrophy (Steinert's disease).

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.

A substituted benzamide anti-psychotic, reported to be a selective antagonist of central dopamine (D-2, D-3 and D-4) receptors, Levosulpiride is also calimed to have mood elevating properties. Levosulpiride is used in the treatment of psychoses, particularly negative symptoms of schizophrenia, anxiety disorders, dysthymia, vertigo, dyspepsia, irritable bowel syndrome and premature ejaculation.

Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. Additionally, it is used for Crohn's disease (inflammatory bowel disease).
 It is marketed by AstraZeneca as a nasal inhalant under the brand name Rhinocort (in Denmark, as Rhinosol), as an oral inhalant under the brand name Pulmicort, and as either an enema or a modified release oral capsule under the brand name Entocort. It is also sold in combination with formoterol (Oxis) in a single inhaler, under the brand name Symbicort. In Brazil it's marketed by Eurofarma under the brand name Noex.

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. It was the first member of a class of anti-cancer drugs which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA which ultimately triggers apoptosis (programmed cell death).

Artemether (INN) is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. It is combined with Lumefantrine and sold by Novartis under the brand names Riamet and Co-Artem.
It is an ether derivative of artemisinin.

Latanoprost is an analogue of prostaglandin F2?; it reduces intraocular pressure (IOP) by increasing outflow of aqueous humour. Timolol is a non-selective adrenergic blocker. It lowers IOP by decreasing the formation of aqueous by the ciliary epithelium.

Flavoxate is an anticholinergic with antimuscarinic effects. Its muscle relaxant properties may be due to a direct action on the smooth muscle rather than by antagonizing muscarinic receptors.

Information Not Available

Acetylcysteine is an antioxidant drug used to reduce the thickness of mucus and ease its removal. It is also used to reverse the toxicity of high doses of acetaminophen. Acetylcysteine with hydration significantly reduces the risk of contrast nephropathy in patients with chronic renal insufficiency. Also called N-acetyl-L-cysteine.

Pseudoephedrine (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It is used as a nasal/sinus decongestant and stimulant, or as a wakefulness-promoting agent.
The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as a single ingredient or, more commonly, in combination with antihistamines, guaifenesin, dextromethorphan, paracetamol (acetaminophen), and/or NSAIDs (e.g., aspirin, ibuprofen, etc.).

Apomorphine is a non-selective dopamine agonist which activates both D1-like and D2-like receptors, with some preference for the latter subtypes.

Lamotrigine by GlaxoSmithKline is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is approved for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants (due to Lamotrigine being a Phenyltriazine), lamotrigine has relatively few side-effects and does not require blood monitoring in monotherapy. The exact way lamotrigine works is unknown. Some think that it is a Na+ (sodium) channel blocker, though it is interesting to note that lamotrigine shares very few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, (e.g. Oxcarbazepine), which may suggest that lamotrigine has a different mechanism of action. The drug information provided at the time of prescription notes that "it is thought to work by restoring the balance of certain natural substances (neurotransmitters) in the brain." Lamotrigine is inactivated by hepatic glucuronidation.

Acitretin (trade name Soriatane) is a second generation retinoid. It is taken orally, and is typically used for psoriasis.
It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.

Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis.

Norfloxacin is a synthetic chemotherapeutic agent occasionally used to treat common as well as complicated urinary tract infections.  It is sold under various brand names with the most common being Noroxin. In form of ophthalmic solutions it is known as Chibroxin. Norfloxacin is a second generation synthetic fluoroquinolone (quinolone) developed by Kyorin Seiyaku K.K. (Kyorin).

Hydrocortisone is the most well-known of the natural metabolic intermediary of cortisols. Cortisol is corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which are a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by CRH. It increases blood pressure and blood sugar, and reduces immune responses. Various synthetic forms of cortisol are used to treat a variety of different illnesses. When first introduced as a treatment for rheumatoid arthritis, hydrocortisone was referred to as Compound E.

Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard. Melphalan is a bifunctional alkylating agent that is active against selected human neoplastic diseases.

Lamivudine (2',3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir, and Epivir-HBV. Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.

Valsartan is an angiotensin II receptor antagonist (more commonly called an "ARB", which stands for angiotensin receptor blocker), with particularly high affinity for the type I (AT1) angiotensin receptor.
Valsartan is marketed by Novartis under the trade name Diovan. In India, it is marketed by CIPLA under the trade name Valtan and by Torrent Pharmaceuticals under the trade name Valzaar.

Metronidazole is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. It is marketed by Pfizer under the trade name Flagyl in the US, by Sanofi-Aventis globally under the same tradename, Flagyl, and by various generic manufacturers.

Metronidazole is also used as a gel preparation in the treatment of the dermatological conditions such as rosacea (Rozex and MetroGel by Galderma) and fungating tumours (Anabact, Cambridge Healthcare Supplies).

Vincristine (brand name, Oncovin), also known as leurocristine, is a vinca alkaloid from the Catharanthus roseus (Madagascar periwinkle), formerly Vinca rosea and hence its name. It is a mitotic inhibitor, and is used in cancer chemotherapy.

Typhoid vaccine is a vaccine used against typhoid.

Types include:

    * Ty21a, which is a live vaccine
    * Vi capsular polysaccharide vaccine, which is a subunit vaccine

Information Not Available

Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid family (which includes diclofenac). Nabumetone has been developed by Beecham. It is available under numerous brand names, such as Relafen, Relifex and Gambaran.

Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin (Schering-Plough Corporation) and Odor Eaters (Combe Incorporated). Other brands are Absorbine, Aftate, Genaspor, Lamasil AF, NP 27, Scholl and Ting.

Information Not Available

Pheniramine is an antihistamine combination. It works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing.

Relieving symptoms of runny nose and sneezing due to colds, upper respiratory infections, and allergies.

Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. It is sold under the brand name Avil by the pharmaceutical company Aventis. Neo Citran contains Pheniramine.

Information Not Available

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination (urge incontinence), by decreasing muscle spasms of the bladder. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. It also has direct spasmolytic effects on bladder smooth muscle as a calcium antagonist and local anesthetic, but at concentrations far above those used clinically. It is available orally in generic formulation and as the brand-names Ditropan and Lyrinel XL, as a transdermal patch under the brand name Oxytrol, and as a topical gel under the brand name Gelnique. Also Ditrospam by Avenzor Syria.

Oxybutynin is also a possible treatment of hyperhidrosis, or hyper-active sweating.

Disopyramide is an antiarrhythmic medication. It is a Class Ia antiarrhythmic (sodium channel blocker) used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors. It resembles Quinidine but it has a marked anti-muscarinic effect on the heart, for this reason, it is not considered as a drug of 1st choice. It is also used in ventricular arrhythmia and supraventricular arrhythmia that might follow myocardial infarctions.

Leuprorelin or leuprolide acetate is a gonadotropin-releasing hormone analog (GnRH analog).
Proper Sequence: p-Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt